反应详情

To an ice cold solution of 1.15 g (3 mmol) of compound 25 in 200 ml of decanted water, 1.5 g (18 mmol) sodium bicarbonate was added. While the mixture was bubbled with N2 gas, 2.09 g (12 mmol) of sodium dithionite was gradually added to the mixture. The mixture was stirred under N2 for 1 hr and then extracted twice, each with 100 ml of ethyl acetate. The combined extract was washed with water, dried over anhydrous Na2SO4 and distilled on rotovap. Yield, 0.38 g (50%) of yellowish semisolid which reduces alcoholic AgNO3TS instantaneously. (PMR as expected).

1. additionwas gradually added to the mixture
2. extractionextracted twice
3. extractionThe combined extract
4. washwas washed with water
5. dry with materialdried over anhydrous Na2SO4
6. distillationdistilled on rotovap
7. customYield