Acetic Anhydride → HCID 18346666, compound

HRID 1633508Notes

Reaction equation

HRID 1633508 reaction equation
[CH3:1][C@H:2]1[NH:8][CH2:7][C:6]2[CH:9]=[CH:10][CH:11]=[CH:12][C:5]=2[NH:4][CH2:3]1.[C:13](OC(=O)C)(=[O:15])[CH3:14].CCN(CC)CC>CN(C=O)C>[CH3:1][C@H:2]1[N:8]([C:13](=[O:15])[CH3:14])[CH2:7][C:6]2[CH:9]=[CH:10][CH:11]=[CH:12][C:5]=2[NH:4][CH2:3]1

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 69299933HCID 69299933, compound

Product 1

HCID 18346666HCID 18346666, compoundYield 34.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

(3R)-3-methyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine (8.6 mmol) was allowed to react with 8.4 mmol acetic anhydride and 12.9 mmol Et3N in 20 mL DMF to give 2.9 mmol of 1-[(3R)-3-methyl-1,2,3,5-tetrahydro-4H-1,4-benzodiazepin4-yl]-1-ethanone.

Sources & evidence

ORD record
ord-e3241c325644415db8aacb5114993cb0
Source dataset
uspto-grants-2003_01
Patent number
US06503900B2

Reaction notes

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