Piperidine → 1-(4-Fluoro-phenyl)-5-(6-piperidin-1-yl-hexyloxy)-1H-indole

HRID 1633617Notes

Reaction equation

HRID 1633617 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=1)[CH:13]=[CH:12]2.[NH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>>[F:24][C:21]1[CH:22]=[CH:23][C:18]([N:14]2[C:15]3[C:11](=[CH:10][C:9]([O:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][N:25]4[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]4)=[CH:17][CH:16]=3)[CH:12]=[CH:13]2)=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 117496125-(6-Bromo-hexyloxy)-1-(4-fluoro-phenyl)-1H-indole

Product 1

HCID 186794321-(4-Fluoro-phenyl)-5-(6-piperidin-1-yl-hexyloxy)-1H-indole

Procedure

In analogy to example 1.4, 5-(6-Bromo-hexyloxy)-1-(4-fluoro-phenyl)-1H-indole and piperidine were converted to yield 1-(4-Fluoro-phenyl)-5-(6-piperidin-1-yl-hexyloxy) -1H-indole as light brown amorphous, MS: 395 (MH+).

Sources & evidence

ORD record
ord-22cb6047e2f54de6912b398d6cbfa36b
Source dataset
uspto-grants-2003_01
Patent number
US06503907B2

Reaction notes

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