Hydrochloric Acid → HCID 18679705, compound

HRID 1633731Notes

Reaction equation

HRID 1633731 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4](/[C:8](/[C:12]2[N:13]=[CH:14][N:15]([S:17]([N:20]([CH3:22])[CH3:21])(=[O:19])=[O:18])[CH:16]=2)=[CH:9]/[O:10][CH3:11])[CH:5]=[CH:6][CH:7]=1.N1C=CC=CC=1.[CH2:29]([S:31](Cl)(=[O:33])=[O:32])[CH3:30].Cl>ClCCl>[CH2:29]([S:31]([NH:1][C:2]1[CH:3]=[C:4](/[C:8](/[C:12]2[N:13]=[CH:14][N:15]([S:17]([N:20]([CH3:22])[CH3:21])(=[O:18])=[O:19])[CH:16]=2)=[CH:9]/[O:10][CH3:11])[CH:5]=[CH:6][CH:7]=1)(=[O:33])=[O:32])[CH3:30]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 11667Ethanesulfonyl chlorideHCID 69987865HCID 69987865, compound

Product 1

HCID 18679705HCID 18679705, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of Example 46B (0.32 g, 0.99 mmol) in dichloromethane (5 mL) was treated with pyridine (0.24 mL, 3.0 mmol), treated with ethanesulfonyl chloride (0.10 mL, 1.1 mmol), stirred for 5 hours, treated with 1M HCl and extracted with dichloromethane (3×). The combined dichloromethane extractions were dried (Na2SO4) and concentrated to provide the title compound.

Workup

  1. extractionextracted with dichloromethane (3×)
  2. extractionThe combined dichloromethane extractions
  3. dry with materialwere dried (Na2SO4)
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-26f3db6ad5a143d9bcc0687cb67bf7fd
Source dataset
uspto-grants-2003_01
Patent number
US06503935B1

Reaction notes

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