反应详情

3-Nitro-5-trifluoromethylbenzonitrile (1 g, 4.63 mmol) was dissolved in methanol (8 mL) and added activated charcoal (0.1 g), FeCl3.6H2O (17 mg, 0.06 mmol) and N,N-dimethylhydrazine (3.7 mL, 48.6 mmol). The mixture was refluxed overnight. The mixture was filtered and the volatiles removed in vacuo. The residue was purified by chromatography on silica using a mixture of heptane and ethyl acetate (4:1) as eluent affording 3-amino-5-trifluoromethylbenzonitrile.

1. temperatureThe mixture was refluxed overnight
2. filtrationThe mixture was filtered
3. customthe volatiles removed in vacuo
4. customThe residue was purified by chromatography on silica using
5. additiona mixture of heptane and ethyl acetate (4:1) as eluent