Catechol → HCID 131723734, compound

HRID 1634000Notes

Reaction equation

HRID 1634000 reaction equation
CC(C(OC)=O)=C.[C:8]([N:10]=[C:11]([NH2:13])[NH2:12])#[N:9].[C:14]1([C:16](=[CH:18][CH:19]=[CH:20][CH:21]=1)[OH:17])[OH:15].CO>CC(C)=O>[C:8]([N:10]=[C:11]([NH2:13])[NH2:12])#[N:9].[C:14]1([C:16](=[CH:18][CH:19]=[CH:20][CH:21]=1)[OH:17])[OH:15]

Participants

6

Reactant 4

HCID 289Catechol3×HCID 887MethanolHCID 6658Methyl MethacrylateHCID 10005Dicyandiamide3×

Product 1

HCID 131723734HCID 131723734, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
45 °C

Procedure

A polymeric solution was prepared by dissolving 40 grams of PMMA-co-PMAA in 700 ml of acetone and heating to 45° C. A second solution was prepared by adding 16 grams of DICY and 16 grams of catechol to 340 ml of methanol. The second solution was added to the first and then stirred for 1 hour at room temperature. The solution was processed through a Buchi™ 190 mini-spray dryer with conditions set as described above, to form particles that are a mixture of DICY and catechol encapsulated in the acrylic polymer. The average particle size was between about 5-10 micrometers with an overall size distribution from about 2 to about 25 micrometers. The particles contain an average of 22% by weight DICY and 22% by weight catechol based on the total particle weight.

Workup

  1. customA polymeric solution was prepared
  2. customA second solution was prepared
  3. additionThe second solution was added to the first and
  4. customto form particles that

Sources & evidence

ORD record
ord-044f622fa11a41b1abae1ced17500655
Source dataset
uspto-grants-2003_01
Patent number
US06506494B2

Reaction notes

Loading…