Dichloromethane → HCID 54232827, compound

HRID 1634143Notes

Reaction equation

HRID 1634143 reaction equation
[C:1]([O:5][C:6](=[O:16])[CH:7]([CH2:11][S:12](Cl)(=[O:14])=[O:13])[CH:8]([CH3:10])[CH3:9])([CH3:4])([CH3:3])[CH3:2].ClCCl.[O:20]1[C:24]2([CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[O:23][CH2:22][CH2:21]1>C(N(CC)CC)C>[C:1]([O:5][C:6](=[O:16])[CH:7]([CH2:11][S:12]([N:27]1[CH2:28][CH2:29][C:24]2([O:23][CH2:22][CH2:21][O:20]2)[CH2:25][CH2:26]1)(=[O:14])=[O:13])[CH:8]([CH3:10])[CH3:9])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 212590942-Chlorosulfonylmethyl-3-methyl-butyric acid tert-butyl ester

Product 1

HCID 54232827HCID 54232827, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

2-Chlorosulfonylmethyl-3-methylbutyric acid tert-butyl ester, dichloromethane (60 ml), triethylamine (82 ml), and 1,4-dioxa-8-aza-spiro[4.5]decane(1.59 g) were reacted as above. Purification by flash chromatography (eluent 50% hexane/diethyl ether) yielded the title compound as a green gum (1.57 g). Rf 0.35 (50% hexane/diethyl ether).

Workup

  1. customPurification by flash chromatography (eluent 50% hexane/diethyl ether)

Sources & evidence

ORD record
ord-d614161e78bd4a04a31474cd5f2fe716
Source dataset
uspto-grants-2003_01
Patent number
US06506764B1

Reaction notes

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