HCID 18677356, compound → HCID 18677360, compound

HRID 1634145Notes

Reaction equation

HRID 1634145 reaction equation
C([O:3][C:4]([CH2:6][N:7]1[C:12]([CH3:13])=[CH:11][N:10]=[C:9]([NH:14][NH2:15])[C:8]1=[O:16])=[O:5])C>Cl>[C:4]([CH2:6][N:7]1[C:12]([CH3:13])=[CH:11][N:10]=[C:9]([NH:14][NH2:15])[C:8]1=[O:16])([OH:5])=[O:3]

Participants

3

Reactant 1

HCID 18677356HCID 18677356, compound

Product 1

HCID 18677360HCID 18677360, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of the compound of Example 4 (6.3 g, 0.028 mol) in HCl (6N, 160 mL) was heated at 60 to 70° C. for 2 hours. The reaction mixture was concentrated under vacuum to afford the title compound (5.0 g, 91%) as a yellow solid, which used in the next step without further purification. 1H NMR (D2O) δ 2.18 (s, 3H), 4.8 (s, 2H), 6.71 (s, 1H).

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum

Sources & evidence

ORD record
ord-ff7b106a0db24791851f92d3147656af
Source dataset
uspto-grants-2003_01
Patent number
US06506760B1

Reaction notes

Loading…