3,4-dihydro-2H-pyran → 5-(Bromomethyl)-1-(2-tetrahydropyranyl)indazole

HRID 1634157Notes

Reaction equation

HRID 1634157 reaction equation
Br.[Br:2][CH2:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][N:8]=[CH:7]2.[O:13]1[CH:18]=[CH:17][CH2:16][CH2:15][CH2:14]1>C1COCC1.C(Cl)Cl>[Br:2][CH2:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18][O:13]1)[N:8]=[CH:7]2

Participants

5

Reactant 2

HCID 80803,4-dihydro-2H-pyranHCID 226614415-(Bromomethyl)-1H-indazole--hydrogen bromide (1/1)2×

Product 1

HCID 105657815-(Bromomethyl)-1-(2-tetrahydropyranyl)indazoleYield 80.8%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8028TetrahydrofuranSolvent

Procedure

A yellow suspension of 5-(bromomethyl)-1H-indazole hydrogen bromide (compound 12-4, 3.0 g, 14 mmol) and 3,4-dihydro-2H-pyran (Aldrich, 2.4 g, 29 mmol) in THF (100 mL) was heated at reflux temperature for 2 hours. After cooling down to room temperature, the reaction mixture was stirred at room temperature for 12 hours under nitrogen. The reaction mixture was diluted with methylene chloride (250 mL), washed with saturated aqueous NaHCO3, water and brine. After drying (MgSO4), the solvent was removed under vacuum to give a yellow oil. Flash chromatography yielded the title compound (12-5, 3.34 g, 80%). TLC Rf 0.58 (70:30 hexane-ethyl acetate); MS (electrospray) 295, 297 (M+1); 1H N MR (CDCl3) δ 1.57-1.84 (m, 3H), 2.16 (m, 2H), 2.55 (m, 1H), 3.75 (m, 1H), 4.01 (m, 1H), 4.65 (s, 2H), 5.71 (d, 1H, J=9.2 Hz), 7.44 (d, 1H, J=8.8 Hz), 7.59 (d, 1H, J=8.8 Hz), 7.73 (s, 1H), 8.00 (s, 1H).

Workup

  1. temperaturewas heated
  2. temperatureat reflux temperature for 2 hours
  3. washwashed with saturated aqueous NaHCO3, water and brine
  4. dry with materialAfter drying (MgSO4)
  5. customthe solvent was removed under vacuum
  6. customto give a yellow oil

Sources & evidence

ORD record
ord-5a5f02e5a31942819a467d500e98b8f4
Source dataset
uspto-grants-2003_01
Patent number
US06506760B1

Reaction notes

Loading…