反应详情

A solution of 1-tert-butoxycarbonyl-3-bromopiperidin-4-one (8 g) and thiobenzamide (3.4 g) in DMF was heated at 70 ° C. for 16 h, then cooled to room temperature. The solvent was evaporated in vacuo and the residue dissolved in water (100 ml) and washed with ether (100 ml), then basified with sodium hydroxide and extracted into ethyl acetate (3×100 ml). The solvent was dried (MgSO4) and evaporated to give the title compound as cream solid (2.81 g, 53% based on thiobenzamide used).

1. customThe solvent was evaporated in vacuo
2. dissolutionthe residue dissolved in water (100 ml)
3. washwashed with ether (100 ml)
4. extractionextracted into ethyl acetate (3×100 ml)
5. dry with materialThe solvent was dried (MgSO4)
6. customevaporated