5-Bromofuran-2-carbaldehyde → HCID 18677549, compound

HRID 1634219Notes

Reaction equation

HRID 1634219 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])[CH:5]=[C:4]([NH2:16])[N:3]=1.C1(C)C=C(C)C=C(C)C=1S([NH:28]O)(=O)=O.[Br:31][C:32]1[O:36][C:35]([CH:37]=O)=[CH:34][CH:33]=1>>[NH2:16][C:4]1[N:3]2[N:28]=[C:37]([C:35]3[O:36][C:32]([Br:31])=[CH:33][CH:34]=3)[N:1]=[C:2]2[CH:7]=[C:6]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])[CH:5]=1

Participants

4

Reactant 3

HCID 6003285-Bromofuran-2-carbaldehydeHCID 11009332O-mesitylenesulfonylhydroxylamineHCID 18677493HCID 18677493, compound

Product 1

HCID 18677549HCID 18677549, compound

Procedure

The title compound, MS m/e (%): 383 (M+H+, 100), was prepared in accordance with the general method of example 373 from (2,6-diamino-pyridin-4-yl)-phenyl-methanone, o-mesitylene-sulfonylhydroxylamine, and 5-bromo-2-furaldehyde. The purification was performed with reversed phase HPLC eluting with an acetonitrile/water gradient.

Sources & evidence

ORD record
ord-5e9c55f1e9de433480488f722b182162
Source dataset
uspto-grants-2003_01
Patent number
US06506772B1

Reaction notes

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