2-Pyridinecarboxaldehyde → HCID 18677525, compound

HRID 1634221Notes

Reaction equation

HRID 1634221 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])[CH:5]=[C:4]([NH2:16])[N:3]=1.C1(C)C=C(C)C=C(C)C=1S([NH:28]O)(=O)=O.[N:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[CH:37]=O>>[NH2:16][C:4]1[N:3]2[N:28]=[C:37]([C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][N:31]=3)[N:1]=[C:2]2[CH:7]=[C:6]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])[CH:5]=1

Participants

4

Reactant 3

HCID 142732-PyridinecarboxaldehydeHCID 11009332O-mesitylenesulfonylhydroxylamineHCID 18677493HCID 18677493, compound

Product 1

HCID 18677525HCID 18677525, compound

Procedure

The title compound, MS m/e (%): 316 (M+H+, 100), was prepared in accordance with the general method of example 373 from (2,6-diamino-pyridin-4-yl)-phenyl-methanone, o-mesitylene-sulfonylhydroxylamine, and pyridine-2-carbaldehyde. The purification was performed with reversed phase HPLC eluting with an acetonitrile/water gradient.

Sources & evidence

ORD record
ord-1ba29f93e8284d2dba40cfb4fe26a2ca
Source dataset
uspto-grants-2003_01
Patent number
US06506772B1

Reaction notes

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