Dimethylformamide → HCID 15450534, compound

HRID 1634315Notes

Reaction equation

HRID 1634315 reaction equation
[C:1]([O:4][C:5]1[CH:16]=[CH:15][C:8]2[S:9][CH:10]=[C:11]([C:12](O)=[O:13])[C:7]=2[CH:6]=1)(=[O:3])[CH3:2].CN(C)C=O.S(Cl)([Cl:24])=O>C1(C)C=CC=CC=1>[C:1]([O:4][C:5]1[CH:16]=[CH:15][C:8]2[S:9][CH:10]=[C:11]([C:12]([Cl:24])=[O:13])[C:7]=2[CH:6]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 15450533HCID 15450533, compound

Product 1

HCID 15450534HCID 15450534, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 1,349 mg of the above obtained 5-acetoxybenzo[b]thiophene-3-carboxylic acid (4), a drop of dimethylformamide, 1.22 ml of (17.13 mmol) of thionyl chloride and 25 ml of toluene was refluxed for 1.5 hours and then concentrated under reduced pressure to give 1,454 mg of the objective compound (5).

Workup

  1. additionA mixture of 1,349 mg of the
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-b4374e36e5f6435bbbfe14f1c7db2aa0
Source dataset
uspto-grants-2003_01
Patent number
US06506789B2

Reaction notes

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