反应详情

A 4 N hydrochloric acid-ethyl acetate solution (30 mL) was dropwise added to an ethyl acetate solution (30 mL) of (R)-2-tert-butoxycarbonylamino-5-(4-chlorophenyl)-5-oxopentanoic acid ethyl ester (5.6 g) at room temperature. The resulting reaction solution was stirred at room temperature for 2 hr and concentrated under reduced pressure to give 5.0 g of a yellow oily substance. To an ethyl acetate solution (100 mL) of this crude product, a saturated sodium hydrogencarbonate aqueous solution (100 mL) was dropwise added. The resulting reaction solution was stirred at room temperature for 20 min and then extracted with ethyl acetate. The extract solution was washed with saturated saline, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give 3.5 g of the title compound as a light yellow oily substance. The physical property values of this compound were as follows:

1. customThe resulting reaction solution
2. concentrationconcentrated under reduced pressure
3. customto give 5.0 g of a yellow oily substance
4. customThe resulting reaction solution
5. stirringwas stirred at room temperature for 20 min
6. extractionextracted with ethyl acetate
7. washThe extract solution was washed with saturated saline
8. dry with materialdried over anhydrous magnesium sulfate
9. concentrationconcentrated under reduced pressure