Aluminium lithium hydride → HCID 178477845, compound

HRID 1634582Notes

Reaction equation

HRID 1634582 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:15](=[C:16]3[CH2:21][CH2:20][N:19]([C:22](=O)[CH2:23][CH2:24][C:25]4[N:26]=[CH:27][NH:28][CH:29]=4)[CH2:18][CH2:17]3)[C:10]3=[N:11][CH:12]=[CH:13][CH:14]=[C:9]3[CH2:8][CH2:7][C:6]=2[CH:31]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1.C(OCC)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:15](=[C:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][CH2:24][C:25]4[N:26]=[CH:27][NH:28][CH:29]=4)[CH2:18][CH2:17]3)[C:10]3=[N:11][CH:12]=[CH:13][CH:14]=[C:9]3[CH2:8][CH2:7][C:6]=2[CH:31]=1

Participants

5

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 178520511HCID 178520511, compound

Product 1

HCID 178477845HCID 178477845, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent2×

Procedure

To a solution of compound (16) (0.65 g; 1.5 mmol) in anhydrous tetrahydrofuran (70 ml) was added a 1.0M solution of lithium aluminum hydride in tetrahydrofuran (4.6 ml; 4.6 mmol). The mixture was stirred at room temperature for 1.75 h. then diluted with ethyl ether and quenched with dropwise addition of saturated ammonium chloride solution. To saturated ammonium chloride

Workup

  1. customquenched with dropwise addition of saturated ammonium chloride solution

Sources & evidence

ORD record
ord-22358971c83f4092b5329af7a85fcbbb
Source dataset
uspto-grants-2003_01
Patent number
US06506756B2

Reaction notes

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