Hydrochloric Acid → HCID 18678400, compound

HRID 1634744Notes

Reaction equation

HRID 1634744 reaction equation
[CH3:1][O:2][CH:3]([O:20][CH3:21])[CH:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:19]=[CH:18][C:13]([C:14]([O:16]C)=[O:15])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1.Cl>CO>[CH3:1][O:2][CH:3]([O:20][CH3:21])[CH:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:19]=[CH:18][C:13]([C:14]([OH:16])=[O:15])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18678451HCID 18678451, compound

Product 1

HCID 18678400HCID 18678400, compoundYield 0.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

A solution of methyl 4-(4-(dimethoxymethyl)piperidinyl)benzoate(5.6 g, 18.2 mol) was in methanol (50 mL) 1N sodium hydroxide (27 mL) was heated at 80° C. for 5 hours. The reaction was neutralized with 1N HCl (27 ml) and concentrated in vacuo. Additional methanol was added to the residue which was filtered (0.5 micron filter) and evaporated to give 5.0 g of the product.

Workup

  1. concentrationconcentrated in vacuo
  2. additionAdditional methanol was added to the residue which
  3. filtrationwas filtered
  4. filtration(0.5 micron filter)
  5. customevaporated

Sources & evidence

ORD record
ord-51422a2766a04a949af58d559798cf72
Source dataset
uspto-grants-2003_01
Patent number
US06506901B2

Reaction notes

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