反应详情

A solution of isonipecotamide (2.0 g, 15.6 mmol), 1-iodopropane (1.52 mL, 15.6 mmol), and potassium carbonate (2.15 g, 15.6 mmol) was heated at reflux in 100 mL of 2-butanone. The solids were filtered and the filtrate concentrated in vacuo to give crude product. Purification by flash chromatography (CH2Cl2—CH3OH, 12:1 ) afforded 1.25 9 of the product as an off-white solid.

1. filtrationThe solids were filtered
2. concentrationthe filtrate concentrated in vacuo
3. customto give crude product
4. customPurification by flash chromatography (CH2Cl2—CH3OH, 12:1 )