4-Piperidinecarboxamide → HCID 18678470, compound

HRID 1634752Notes

Reaction equation

[NH:1]1[CH2:9][CH2:8][CH:4]([C:5]([NH2:7])=[O:6])[CH2:3][CH2:2]1.[F:10][C:11]([F:16])([F:15])[CH2:12][CH2:13]I.C(=O)([O-])[O-].[K+].[K+]>>[F:10][C:11]([F:16])([F:15])[CH2:12][CH2:13][N:1]1[CH2:9][CH2:8][CH:4]([C:5]([NH2:7])=[O:6])[CH2:3][CH2:2]1

Participants

Reactant 3

HCID 37724-Piperidinecarboxamide

HCID 11430Potassium Carbonate

HCID 1561651,1,1-Trifluoro-3-iodopropane

Product 1

HCID 18678470HCID 18678470, compoundYield 23.4%

Procedure

Prepared from isonipecotamide (2.85 g, 22.3 mmol), 3,3,3-trifluoropropyl iodide (5 g, 22.3 mmol) and potassium carbonate (3.08 g, 22.3 mmol) of according to the procedure used for Example 8 (Step A) to give 1.17 g of the title compound.

Sources & evidence

ORD record: ord-7a731ffcfcdd46eba37e816b0b9b6607
Source dataset: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06506901B2

Reaction notes

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