4-Piperidinecarboxamide → HCID 18678407, compound

HRID 1634766Notes

Reaction equation

[NH:1]1[CH2:9][CH2:8][CH:4]([C:5]([NH2:7])=[O:6])[CH2:3][CH2:2]1.[F:10][C:11]([F:17])([F:16])[CH2:12][CH2:13][CH2:14]I.C(=O)([O-])[O-].[K+].[K+]>>[F:10][C:11]([F:17])([F:16])[CH2:12][CH2:13][CH2:14][N:1]1[CH2:9][CH2:8][CH:4]([C:5]([NH2:7])=[O:6])[CH2:3][CH2:2]1

Participants

Reactant 3

HCID 37724-Piperidinecarboxamide

HCID 11430Potassium Carbonate

HCID 27751891,1,1-Trifluoro-4-iodobutane

Product 1

HCID 18678407HCID 18678407, compoundYield 106.8%

Procedure

Prepared from isonipecotamide (0.422 g, 3.3 mmol), 4,4,4-trifluorobutyliodide (0.82 g, 3.4 mmol) and potassium carbonate (0.47 g, 3.4 mmol) according to the procedure used for Example 8 (Step A) to give 0.84 g of the title compound as a white solid.

Sources & evidence

ORD record: ord-5b70c2deecd34d76863d6f0fa0c5e003
Source dataset: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06506901B2

Reaction notes

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