Sodium Iodide → HCID 18678744, compound

HRID 1634810Notes

Reaction equation

[F:1][C:2]1[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[C:3]=1[CH2:4][N:5]([CH3:29])[C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([S:15]([N:18]2[CH2:23][CH2:22][CH:21]([CH:24](OC)[O:25]C)[CH2:20][CH2:19]2)(=[O:17])=[O:16])=[CH:11][CH:10]=1)=[O:7].[I-].[Na+].ClC([SiH3])(Cl)Cl>>[F:34][C:30]1[CH:31]=[CH:32][CH:33]=[C:2]([F:1])[C:3]=1[CH2:4][N:5]([CH3:29])[C:6]([NH:8][C:9]1[CH:10]=[CH:11][C:12]([S:15]([N:18]2[CH2:19][CH2:20][CH:21]([CH:24]=[O:25])[CH2:22][CH2:23]2)(=[O:17])=[O:16])=[CH:13][CH:14]=1)=[O:7]

Participants

Reactant 3

HCID 5238Sodium Iodide

HCID 18678450HCID 18678450, compound

HCID 71317501CID 71317501

Product 1

HCID 18678744HCID 18678744, compound

Procedure

The title compound was prepared from 1-(2,6-difluoro-benzyl)-3-[4-(4-dimethoxymethyl-piperidine-1-sulfonyl)-phenyl]-1-methyl-urea (0.250 g, 0.5 mmol), sodium iodide (0.188 g, 1.26 mmol), and trichloromethylsilane (0.118 mL, 1.0 mmol) according to the procedure used for example 84 (Step D) and used directly in the next step.

Sources & evidence

ORD record: ord-8ca48cf9f5d347cfb59593a7cf865eaf
Source dataset: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06506901B2

Reaction notes

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