Isopropylamine → 2,5-Difluoro-N-(1-methylethyl)benzamide

HRID 1634812Notes

Reaction equation

[F:1][C:2]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:3]=1[C:4]([OH:6])=O.C(N1C=CN=C1)(N1C=CN=C1)=O.[CH:24]([NH2:27])([CH3:26])[CH3:25]>>[F:1][C:2]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:3]=1[C:4]([NH:27][CH:24]([CH3:26])[CH3:25])=[O:6]

Participants

Reactant 3

HCID 6363Isopropylamine

HCID 682631,1'-Carbonyldiimidazole

HCID 763392,5-Difluorobenzoic acid

Product 1

HCID 176832992,5-Difluoro-N-(1-methylethyl)benzamide

Procedure

The title compound was prepared from 2,5-difluorobenzoic acid (10 g, 63.2 mmol), carbonyldiimidazole (9.57 g, 61 mmol) and isopropyl amine (5.15 mL, 60.5 mmol) according to the procedure used for example 84 (Step A) to give near quantitative yield of the title compound.

Sources & evidence

ORD record: ord-1e62e3fac67c4e4bbaed1647e65dc3a1
Source dataset: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06506901B2

Reaction notes

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