Diisopropylethylamine → HCID 59032956, compound

HRID 1634823Notes

Reaction equation

C([Si]([O:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][CH2:26][C@@H:27]2[CH2:29][O:28]2)=[CH:21][CH:20]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C.C(O)=O.[NH2:33][CH2:34][CH:35]1[CH2:40][CH2:39][N:38]([S:41]([C:44]2[CH:49]=[CH:48][C:47]([NH:50][C:51]([C:53]3[C:61]4[C:56](=[CH:57][CH:58]=[CH:59][CH:60]=4)[NH:55][N:54]=3)=[O:52])=[CH:46][CH:45]=2)(=[O:43])=[O:42])[CH2:37][CH2:36]1.C(N(C(C)C)CC)(C)C>>[OH:28][C@H:27]([CH2:26][O:25][C:22]1[CH:21]=[CH:20][C:19]([OH:18])=[CH:24][CH:23]=1)[CH2:29][NH:33][CH2:34][CH:35]1[CH2:36][CH2:37][N:38]([S:41]([C:44]2[CH:49]=[CH:48][C:47]([NH:50][C:51]([C:53]3[C:61]4[C:56](=[CH:57][CH:58]=[CH:59][CH:60]=4)[NH:55][N:54]=3)=[O:52])=[CH:46][CH:45]=2)(=[O:42])=[O:43])[CH2:39][CH2:40]1

Participants

Reactant 3

HCID 81531Diisopropylethylamine

HCID 11327180t-butyl-[4-(2S)-oxiranylmethoxy-phenoxy]-diphenylsilane

HCID 86758801HCID 86758801, compound

Product 1

HCID 59032956HCID 59032956, compoundYield 13.4%

Procedure

Prepared from t-butyl-[4-(2S)-oxiranylmethoxy-phenoxy]-diphenylsilane (0.623 g, 1.54 mmol), (1H)-Indazole-3-carboxylic acid [4-(4-aminomethyl-1-piperidinyl-sulfonyl)-phenyl]-amide formate salt (0.71 g, xx mmol) and diisopropylethyl amine (0.41 mL) according to the procedure used for example 37 to give 0.12 g of the title compound as a white solid.

Sources & evidence

ORD record: ord-1c8268de2e234750ac0c3a82980751ad
Source dataset: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06506901B2

Reaction notes

Loading…