Trifluoroacetic acid → HCID 88098135, compound

HRID 1634842Notes

Reaction equation

HRID 1634842 reaction equation
[CH2:1]([O:8][C:9](=[O:42])[C@H:10]([NH:22][C:23](=[O:41])[C:24]1[CH:29]=[CH:28][C:27]([N:30]2[CH2:35][CH2:34][CH:33]([CH:36](OC)[O:37]C)[CH2:32][CH2:31]2)=[CH:26][CH:25]=1)[CH2:11][C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:1]([O:8][C:9](=[O:42])[C@H:10]([NH:22][C:23](=[O:41])[C:24]1[CH:29]=[CH:28][C:27]([N:30]2[CH2:31][CH2:32][CH:33]([CH:36]=[O:37])[CH2:34][CH2:35]2)=[CH:26][CH:25]=1)[CH2:11][C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 70000063HCID 70000063, compound

Product 1

HCID 88098135HCID 88098135, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of (2R)-2-{[4-(4-(dimethoxymethyl)piperidin-1-yl)benzoyl]-amino}-butanedioic acid dibenzyl ester (0.215 g, 0.4 mol) in methylene chloride (10 mL) containing trifluoroacetic acid (0.165 mL, 2.0 mmol) was stirred at ambient temperature for 1 hour. The reaction was concentrated in vacuo to give the product which was used directly in the next step.

Workup

  1. concentrationThe reaction was concentrated in vacuo
  2. customto give the product which

Sources & evidence

ORD record
ord-ce997d76b958428b99e3b465b302a734
Source dataset
uspto-grants-2003_01
Patent number
US06506901B2

Reaction notes

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