反应详情

温度

90 °C

3,4,5-Trimethoxyphenylboronic acid (639 mg) and ethyl 2-bromobenzoate (479 mg) were suspended in a mixed solvent of toluene (20 mL) and THF (15 mL), and to the suspension 2M sodium carbonate (6 mL) and tetrakis (triphenylphosphine) palladium(0) (175 mg) were added. The mixture was stirred overnight at 90° C. under an argon atmosphere. Ethyl acetate was added to the reaction mixture to separate an organic layer. The organic layer was washed with saturated brine, dried over anhydrous sodium magnesium and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=5:1) to obtain the title compound.

1. customto separate an organic layer
2. washThe organic layer was washed with saturated brine
3. dry with materialdried over anhydrous sodium magnesium
4. concentrationconcentrated under reduced pressure
5. customThe residue was purified by column chromatography on silica gel (hexane:ethyl acetate=5:1)