HCID 18676179, compound → HCID 18676177, compound

HRID 1635579Notes

Reaction equation

HRID 1635579 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([O:10][CH3:11])[CH:5]=[CH:4][C:3]=1[N:12]([CH2:20][C:21]1[N:22]([CH2:28][C:29]2[CH:39]=[CH:38][CH:37]=[CH:36][C:30]=2[O:31][CH2:32][C:33]([O-:35])=[O:34])[C:23]([CH3:27])=[C:24]([CH3:26])[N:25]=1)[C:13]([CH2:15][CH2:16][CH:17]([CH3:19])[CH3:18])=[O:14]>Cl>[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([O:10][CH3:11])[CH:5]=[CH:4][C:3]=1[N:12]([CH2:20][C:21]1[N:22]([CH2:28][C:29]2[CH:39]=[CH:38][CH:37]=[CH:36][C:30]=2[O:31][CH2:32][C:33]([OH:35])=[O:34])[C:23]([CH3:27])=[C:24]([CH3:26])[N:25]=1)[C:13]([CH2:15][CH2:16][CH:17]([CH3:19])[CH3:18])=[O:14]

Participants

3

Reactant 1

HCID 18676179HCID 18676179, compound

Product 1

HCID 18676177HCID 18676177, compoundYield 101.5%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 58 mg of {2-[(2-{[(2-chloro-3,4-dimethoxyphenyl)-N-(3-methylbutyl)carbonylamino]methyl}-4,5-dimethylimidazol-1-yl)methyl]phenoxy}acetate in 2 mL of 5N HCl is heated under reflux for 15 min. The volatiles are evaporated under reduced pressure, and the residue is dried in a vacuum oven at 90° C. to give 59 mg of the title compound as the hydrochloride salt. Mass Spec m/z (M++1) 558.

Workup

  1. temperatureunder reflux for 15 min
  2. customThe volatiles are evaporated under reduced pressure
  3. customthe residue is dried in a vacuum oven at 90° C.

Sources & evidence

ORD record
ord-2f8e4a8c22f04624b29b0781ec01b2d0
Source dataset
uspto-grants-2003_01
Patent number
US06509366B2

Reaction notes

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