Trifluoroacetic acid → HCID 12096144, compound

HRID 1635647Notes

Reaction equation

[CH3:1][C@H:2]1[CH2:7][CH2:6][CH2:5][C@@H:4]([CH3:8])[N:3]1[CH2:9][CH2:10][NH:11][C:12]([C@@H:14]1[CH2:19][CH2:18][CH2:17][CH2:16][N:15]1C(OC(C)(C)C)=O)=[O:13].FC(F)(F)C(O)=O>>[CH3:8][C@H:4]1[CH2:5][CH2:6][CH2:7][C@@H:2]([CH3:1])[N:3]1[CH2:9][CH2:10][NH:11][C:12]([C@@H:14]1[CH2:19][CH2:18][CH2:17][CH2:16][NH:15]1)=[O:13]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 54019480HCID 54019480, compound

Product 1

HCID 12096144HCID 12096144, compound

Procedure

The title compound was prepared by a similar method to Example 8 from tert-butyl (2S)-2-[(2-[(cis)-2,6-dimethyl-1-piperidinyl]ethylamino)carbonyl]-1-piperidinecarboxylate [see Preparation 14] and trifluoroacetic acid, to afford (2S)-N2-2-[(cis)-2,6-dimethyl-1-piperidinyl]ethyl-2-piperidinecarboxamide as a gum.

Sources & evidence

ORD record: ord-6504baf1fa3547b5b4e9f966af5124d5
Source dataset: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06509464B1

Reaction notes

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