Tetrahydrofuran → HCID 9948357, compound

2.03 ml of a 30% solution of sodium methoxide in methanol were added dropwise (such that the temperature did not exceed 15° C.) to a solution of 980 μl of methyl thioglycolate in 10 ml of methanol at 10° C., under an inert atmosphere. The mixture was maintained under stirring for 30 min and then added to a solution of 2.5 g of 1-chloro-5-thia-2-tridecyne in a mixture of 7 ml of methanol with 3 ml of THF under an inert atmosphere. The mixture was maintained under stirring for 15 hours at room temperature and then the reaction medium was poured over 100 ml of acid water (98 ml of water+2 ml concentrated H2SO4) and then extracted 3 times with ethyl ether. The combined organic phases were washed 3 times with water and then with a saturated aqueous solution of NaCl before being dried (Na2SO4), filtered and concentrated under vacuum in a rotary evaporator. The oily residue obtained was chromatographed on a silica gel column (CH2Cl2) providing 2.3 grams of methyl 3,8-dithia-5-hexadecynoate in the form of a pale orange-colored oil (yield 71%).

1. customdid not exceed 15° C.
2. customat 10° C.
3. temperatureThe mixture was maintained
4. temperatureThe mixture was maintained
5. stirringunder stirring for 15 hours at room temperature
6. extractionextracted 3 times with ethyl ether
7. washThe combined organic phases were washed 3 times with water
8. dry with materialwith a saturated aqueous solution of NaCl before being dried (Na2SO4)
9. filtrationfiltered
10. concentrationconcentrated under vacuum in a rotary evaporator
11. customThe oily residue obtained
12. customwas chromatographed on a silica gel column (CH2Cl2)

ORD record

ord-a1e5f4c4abad4cddb02bc7148d637491

Source dataset

uspto-grants-2003_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06511670B1