Sodium hydride → HCID 9890529, compound

HRID 1635807Notes

Reaction equation

HRID 1635807 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[CH2:14][N:13]3[CH:21]=[CH:22][CH:23]=[C:12]3[CH2:11]2)=[O:9])=[C:4]([C:24]([F:27])([F:26])[F:25])[CH:3]=1.[H-].[Na+].[CH:30]1([C:33]2[CH:37]=[CH:36][NH:35][N:34]=2)[CH2:32][CH2:31]1>CN(C)C=O>[CH:30]1([C:33]2[CH:37]=[CH:36][N:35]([C:2]3[CH:7]=[CH:6][C:5]([C:8]([N:10]4[C:16]5[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=5[CH2:14][N:13]5[CH:21]=[CH:22][CH:23]=[C:12]5[CH2:11]4)=[O:9])=[C:4]([C:24]([F:25])([F:26])[F:27])[CH:3]=3)[N:34]=2)[CH2:32][CH2:31]1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 9799697HCID 9799697, compoundHCID 178419915HCID 178419915, compound

Product 1

HCID 9890529HCID 9890529, compoundYield 69.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In the manner of Example 2, employing (4-fluoro-2-trifluoromethyl-phenyl)-(5H,11H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-methanone (1.42 g), 60% sodium hydride in oil (0.20 g), 3-cyclopropylpyrazole (0.43 g) and dimethylformamide (50 ml), the product (1.22 g) was obtained as a crystalline solid, m.p. 163-164° C.

Sources & evidence

ORD record
ord-58d652e738c04d82a747a4b491b78dad
Source dataset
uspto-grants-2003_01
Patent number
US06511974B1

Reaction notes

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