Hexane → HCID 9911942, compound

HRID 1635814Notes

Reaction equation

HRID 1635814 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](F)[CH:5]=[CH:4][C:3]=1[C:9]([N:11]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[CH2:15][N:14]2[CH:22]=[CH:23][CH:24]=[C:13]2[CH2:12]1)=[O:10].[H-].[Na+].CCCCCC.[F:33][C:34]([F:41])([F:40])[C:35]1[CH:39]=[CH:38][NH:37][N:36]=1>CN(C)C=O>[Cl:1][C:2]1[CH:7]=[C:6]([N:37]2[CH:38]=[CH:39][C:35]([C:34]([F:41])([F:40])[F:33])=[N:36]2)[CH:5]=[CH:4][C:3]=1[C:9]([N:11]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[CH2:15][N:14]2[CH:22]=[CH:23][CH:24]=[C:13]2[CH2:12]1)=[O:10]

Participants

6

Reactant 4

HCID 8058HexaneHCID 24758Sodium hydrideHCID 18070343-(Trifluoromethyl)pyrazoleHCID 9798048HCID 9798048, compound

Product 1

HCID 9911942HCID 9911942, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In the manner of Example 9's Method 1, employing (2-chloro-4-fluorophenyl)-(5H,11H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-methanone (0.8 g), 60% sodium hydride in oil (0.25 g, degreased with hexane), 3-trifluoromethylpyrazole (0.61 g) and dimethylformamide (25 ml), the title compound was obtained as an amorphous solid, MS, m/z: 457.2 (M+H)+.

Sources & evidence

ORD record
ord-6f05b08c6f734b9bbb93d2ce03edfe26
Source dataset
uspto-grants-2003_01
Patent number
US06511974B1

Reaction notes

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