Trifluoroacetic acid → HCID 23557283, compound

HRID 1635891Notes

Reaction equation

HRID 1635891 reaction equation
[CH3:1][O:2][C:3](=[O:24])/[CH:4]=[CH:5]/[CH:6]=[CH:7]/[CH2:8][CH:9]([C:17]([O:19]C(C)(C)C)=[O:18])[C:10]([O:12]C(C)(C)C)=[O:11].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:24])/[CH:4]=[CH:5]/[CH:6]=[CH:7]/[CH2:8][CH:9]([C:10]([OH:12])=[O:11])[C:17]([OH:19])=[O:18]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23557315HCID 23557315, compound

Product 1

HCID 23557283HCID 23557283, compoundYield 83.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of 40 (200 mg, 0.59 mmol) in CH2Cl2 (10 mL) was added TFA (1 mL). The reaction was allowed to proceed overnight. Volatiles were removed under reduced pressure to leave 41 as a white solid (112 mg, 0.49 mmol, 83%). 1H-NMR (CD3OD, 400 MHz) δ 7.11 (dd, 1H), 6.33 (dd, 1H), 6.16 (m, 1H), 5.81 (d, 1H), 3.76 (s, 3H), 3.15 (t, 1H), 2.70 (t, 2H).

Workup

  1. customVolatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-9ccb139e47e047fc9552b562fcc3daa9
Source dataset
uspto-grants-2003_01
Patent number
US06511990B1

Reaction notes

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