Aniline → HCID 564422, compound

To a stirred solution of oxalyl chloride (2.0 M in CH2Cl2, 11.5 mL, 23.1 mmol) in CH2Cl2 (100 mL) and DMF (1 drop) at 0° C. was added 4-pentenoic acid (2.25 mL, 22.0 mmol). This was allowed to warm to ambient temperature. Upon cessation of gas evolution, the mixture was returned to 0° C. and a solution of aniline (2.00 mL, 22.0 mmol) and TEA (6.72 mL, 26.3 mmol) in CH2Cl2 (5 mL) was added dropwise. After warming to ambient temperature, the reaction was allowed to proceed for 3 h. The mixture was concentrated under reduced pressure, and then partitioned between HCl (1 N, 10 mL) and EtOAc (30 mL) and the layers separated. The aqueous portion was extracted with EtOAc (3×15 mL) and the organic layers combined, washed with brine, dried over MgSO4, and filtered. Concentration under reduced pressure gave a yellowish solid, which was recrystallized with toluene to obtain 42 as white crystals (1.97 g, 11.24 mmol, 51%). TLC Rf 0.68 (50% EtOAc/hexanes); 1H-NMR (300 MHz, CDCl3) δ 7.49 (d, 2H), 7.29 (t, 2H), 7.08 (t, 1H), 5.88 (m, 1H), 5.10 (dd, 2 H), 4.42 (br s, 4 H).

1. customwas returned to 0° C.
2. temperatureAfter warming to ambient temperature
3. concentrationThe mixture was concentrated under reduced pressure
4. custompartitioned between HCl (1 N, 10 mL) and EtOAc (30 mL)
5. customthe layers separated
6. extractionThe aqueous portion was extracted with EtOAc (3×15 mL)
7. washwashed with brine
8. dry with materialdried over MgSO4
9. filtrationfiltered
10. concentrationConcentration under reduced pressure
11. customgave a yellowish solid, which
12. customwas recrystallized with toluene

ORD record

ord-df29b6affd0142f18406b675f9c0260b

Source dataset

uspto-grants-2003_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06511990B1