Hydrochloric Acid → HCID 69693082, compound

HRID 1635925Notes

Reaction equation

HRID 1635925 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:12][N:11]=[C:10]([NH:13][C:14](=[O:25])[C@H:15]([CH3:24])[NH:16]C(OC(C)(C)C)=O)[C:9]=2[C:26]2[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=2)=[CH:4][CH:3]=1.[ClH:32]>C(OCC)(=O)C>[ClH:32].[NH2:16][C@H:15]([C:14]([NH:13][C:10]1[C:9]([C:26]2[CH:27]=[CH:28][N:29]=[CH:30][CH:31]=2)=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[NH:12][N:11]=1)=[O:25])[CH3:24]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15513095HCID 15513095, compound

Product 1

HCID 69693082HCID 69693082, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

80 mg of 5-(4-fluorophenyl)-3-(N′-carbo-t-butoxy-L-alanylamino)-4-(4-pyridyl)pyrazole was dissolved in 2 ml of ethyl acetate. Then, 5 ml of a 2.9 mol/L solution of HCl in ethyl acetate was added thereto, followed by stirring at room temperature overnight. After the reaction mixture was concentrated under reduced pressure, the resulting residue was suspended in ethyl acetate. The precipitated powder was collected by filtration to obtain 60 mg (73% yield) of the title compound as a white powder.

Workup

  1. concentrationAfter the reaction mixture was concentrated under reduced pressure
  2. filtrationThe precipitated powder was collected by filtration

Sources & evidence

ORD record
ord-da4c5322ce9b42f38992de6118d6a414
Source dataset
uspto-grants-2003_01
Patent number
US06511997B1

Reaction notes

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