8-(9H-carbazol-2-yloxy)-octanoic acid benzyloxyamide → HCID 9967789, compound

HRID 1636068Notes

Reaction equation

HRID 1636068 reaction equation
C([O:8][NH:9][C:10](=[O:32])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][O:18][C:19]1[CH:31]=[CH:30][C:29]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[NH:22][C:21]=2[CH:20]=1)C1C=CC=CC=1>O1CCCC1.[Pd]>[OH:8][NH:9][C:10](=[O:32])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][O:18][C:19]1[CH:31]=[CH:30][C:29]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[NH:22][C:21]=2[CH:20]=1

Participants

4

Reactant 1

HCID 865865438-(9H-carbazol-2-yloxy)-octanoic acid benzyloxyamide

Product 1

HCID 9967789HCID 9967789, compoundYield 0%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

In a manner anologous to that of example 1(c), 8-(9H-carbazol-2-yloxy)-octanoic acid benzyloxyamide (90 mg, 430 mmol) in tetrahydrofuran was hydrogenated in the presence of palladium on barium sulfate to give the title compound as a crystalline solid (16 mg). MS (M−H+)=339.

Sources & evidence

ORD record
ord-3baacf172d4b45bfbb116e363b726e64
Source dataset
uspto-grants-2003_01
Patent number
US06512123B2

Reaction notes

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