Lithium Hydroxide → HCID 18674669, compound

HRID 1636074Notes

Reaction equation

HRID 1636074 reaction equation
[CH:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][C:2]=1[O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([O:22]CC)=[O:21].[OH-].[Li+]>CO>[CH:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][C:2]=1[O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([OH:22])=[O:21]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 18674684HCID 18674684, compound

Product 1

HCID 18674669HCID 18674669, compoundYield 96.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 6-(9H-carbazol-2-yloxy)-hexanoate (270 mg, 0.8 mmol) and 1 N aqueous lithium hydroxide (2 ml, 2 mmol) in 15 ml methanol was heated to reflux for 1h. The solvent was removed, the residue was acidified by 1 ml 2N aqueous hydrochloric acid. The precipitate was collected to give 6-(9H-carbazol-2-yloxy)-hexanoic acid (230 mg, 93%) as a colorless solid. MS (M−H+)296.

Workup

  1. temperatureto reflux for 1h
  2. customThe solvent was removed
  3. customThe precipitate was collected

Sources & evidence

ORD record
ord-35cb632fd95649e48b44a8238e70dd4e
Source dataset
uspto-grants-2003_01
Patent number
US06512123B2

Reaction notes

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