反应详情

Sodium hydride (900 mg, 60% dispersion in mineral oil, 22.5 mmol) was added portionwise to an ice-cold solution of 2-(benzyloxy)ethanol (3.0 g, 20.0 mmol) in toluene (100 ml), and the solution stirred for 30 minutes. 2,6-Dibromopyridine (4.75 g, 20.0 mmol) was added, and the reaction heated under reflux for 2 hours. The cooled mixture was diluted with water (100 ml), and extracted with ethyl acetate (3×100 ml). The combined organic extracts were dried (MgSO4), filtered and evaporated in vacuo to give the title compound as a yellow oil, (quantitative).

1. temperaturethe reaction heated
2. temperatureunder reflux for 2 hours
3. extractionextracted with ethyl acetate (3×100 ml)
4. dry with materialThe combined organic extracts were dried (MgSO4)
5. filtrationfiltered
6. customevaporated in vacuo