Thionyl Chloride → HCID 17770918, compound

HRID 1636281Notes

Reaction equation

HRID 1636281 reaction equation
S(Cl)([Cl:3])=O.[F:5][C:6]1[C:14]([C:15]([F:18])([F:17])[F:16])=[C:13]([F:19])[C:12]([F:20])=[CH:11][C:7]=1[C:8](O)=[O:9]>CN(C)C=O.C1C=CC=CC=1>[F:5][C:6]1[C:14]([C:15]([F:18])([F:17])[F:16])=[C:13]([F:19])[C:12]([F:20])=[CH:11][C:7]=1[C:8]([Cl:3])=[O:9]

Participants

5

Reactant 2

HCID 24386Thionyl Chloride2×HCID 142788272,4,5-Trifluoro-3-(trifluoromethyl)benzoic acid

Product 1

HCID 17770918HCID 17770918, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 241BenzeneSolvent2×

Procedure

30 ml of benzene, 17 ml of thionyl chloride and several drops of N,N-dimethylformamide were added to 8.5 g (0.0348 mole) of 2,4,5-trifluoro-3-trifluoromethylbenzoic acid (VII), and the mixture was refluxed under heating for 3 hours. After the reaction, benzene and excess thionyl chloride were removed by evaporation under reduced pressure to obtain 2,4,5-trifluoro-3-trifluoromethylbenzoic acid chloride (VIII).

Workup

  1. temperaturethe mixture was refluxed
  2. temperatureunder heating for 3 hours
  3. customwere removed by evaporation under reduced pressure

Sources & evidence

ORD record
ord-5555a0aac2d74b81ac5acd052400a5bd
Source dataset
uspto-grants-2000_03
Patent number
US06034086

Reaction notes

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