反应详情

Triethylamine was added to a solution of 6-bromo-4-chloro-3-propyl-2H-1-benzopyran-2-one (0.5 g), in dry ethanol (10 ml) followed by 2-methoxyethylamine (0.16 ml). The mixture was heated at reflux under nitrogen overnight, evaporated and the residue extracted with ethyl acetate and the extract washed with dilute hydrochloric acid, brine, dried and evaporated under reduced pressure. The residue was triturated with ethanol and light petroleum (b.p. 40-60° C.) to give 6-bromo-4-(2-methoxyethylamino)-3-propyl-2H-1-benzopyran-2-one, m.p. 75-7° C. (compound 21).

1. temperatureThe mixture was heated
2. temperatureat reflux under nitrogen overnight
3. customevaporated
4. extractionthe residue extracted with ethyl acetate
5. washthe extract washed with dilute hydrochloric acid, brine
6. customdried
7. customevaporated under reduced pressure
8. customThe residue was triturated with ethanol and light petroleum (b.p. 40-60° C.)