反应详情

Propionyl chloride (2.5 g, 27.0 mmols) was gradually and dropwise added to a tetrahydrofuran (20 ml) solution containing 2-(5-fluoro-6-methoxyindan-1-yl)ethylamine (4.35 g, 20.8 mmols) and triethylamine (4.21 g, 41.6 mmols) while cooling with ice. After having been stirred at room temperature for 2 hours, the reaction mixture was poured into water, and the organic substance was extracted out with ethyl acetate. The extract was washed with a saturated saline solution and water and then dried with anhydrous magnesium sulfate, and the solvent was removed through distillation under reduced pressure. The resulting residue was purified through silica-gel column chromatography (ethyl acetate/hexane=90/10) to obtain 4.87 g (yield: 88%) of the target compound.

1. temperaturewhile cooling with ice
2. extractionthe organic substance was extracted out with ethyl acetate
3. washThe extract was washed with a saturated saline solution and water
4. dry with materialdried with anhydrous magnesium sulfate
5. customthe solvent was removed through distillation under reduced pressure
6. customThe resulting residue was purified through silica-gel column chromatography (ethyl acetate/hexane=90/10)