反应详情

温度

120 °C

Potassium carbonate (1.37 g, 9.95 mmols) and propargyl bromide (2.4 g, 19.9 mmols) were added to a dimethylformamide (10 ml) solution of N-[2-(5-fluoro-6-hydroxyindan-1-yl)ethyl]propionamide (0.5 g, 1.99 mmols) and stirred at 120° C. for 2 hours. The reaction solution was poured into water, and the organic substance was extracted out with ethyl acetate. The extract was washed with a saturated saline solution and water and then dried with anhydrous magnesium sulfate, and the solvent was removed through distillation under reduced pressure. The resulting residue was purified through silica-gel column chromatography (ethyl acetate) to obtain 0.56 g (yield: 97%) of the target compound.

1. extractionthe organic substance was extracted out with ethyl acetate
2. washThe extract was washed with a saturated saline solution and water
3. dry with materialdried with anhydrous magnesium sulfate
4. customthe solvent was removed through distillation under reduced pressure
5. customThe resulting residue was purified through silica-gel column chromatography (ethyl acetate)