Potassium Carbonate → HCID 18434337, compound

HRID 1636754Notes

Reaction equation

HRID 1636754 reaction equation
Br[CH2:2]/[CH:3]=[CH:4]/[CH2:5][OH:6].C([O-])([O-])=O.[K+].[K+].[CH2:13]([NH:16][CH3:17])[CH:14]=[CH2:15]>CC(C)=O>[CH2:13]([N:16]([CH3:17])[CH2:2]/[CH:3]=[CH:4]/[CH2:5][OH:6])[CH:14]=[CH2:15]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 69391N-MethylallylamineHCID 11423688HCID 11423688, compound

Product 1

HCID 18434337HCID 18434337, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

3.58 g of (E)-4-bromo-2-buten-1-ol are dissolved in 100 ml of acetone and treated with 9.84 g of K2CO3 and 3.4 ml of N-allyl-methyl-amine. The suspension is stirred at RT for 40 h., filtered and the crude product obtained after concentration is purified on silica gel with methylene chloride:methanol (gradient 9:1-3:1). 1.52 g of (E)-4-(allyl-methyl-amino)-but-2-en-1-ol are obtained as a colourless liquid, MS: m/e 141 (M).

Workup

  1. filtrationfiltered
  2. customthe crude product obtained
  3. concentrationafter concentration
  4. customis purified on silica gel with methylene chloride

Sources & evidence

ORD record
ord-d91cc19892654a8cb4d726cc4fc4321a
Source dataset
uspto-grants-2000_03
Patent number
US06034275

Reaction notes

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