Hydrochloric Acid → HCID 21187705, compound

HRID 1637079Notes

Reaction equation

HRID 1637079 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1([OH:18])[CH2:17][CH2:16][C:11]2([O:15]CCO2)[CH2:10][CH2:9]1.Cl.C(=O)(O)[O-].[Na+]>O1CCOCC1>[CH2:8]([O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1([OH:18])[CH2:9][CH2:10][C:11](=[O:15])[CH2:16][CH2:17]1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:2]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 21187682HCID 21187682, compound

Product 1

HCID 21187705HCID 21187705, compoundYield 162.9%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of of 8-(2-Hydroxy-phenyl)-1,4-dioxa-spiro[4.5]decan-8-ol (2.76 g, 8.12 mmol) in 70 mL 1,4-dioxane was added aqueous hydrogen chloride (40.6 mL 1M, 40.6 mmol). The solution was stirred for 30 min., poured onto saturated sodium bicarbonate, and extracted with ethylacetate. The combined organic layers were washed with saturated sodium chloride, dried with magnesium sulfate, and concentrated in vacuo to give the product (1.96 g, 82%).

Workup

  1. extractionextracted with ethylacetate
  2. washThe combined organic layers were washed with saturated sodium chloride
  3. dry with materialdried with magnesium sulfate
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-8890dfbe61654b288b5fdbd265cddb2e
Source dataset
uspto-grants-2000_03
Patent number
US06037354

Reaction notes

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