反应详情

温度

80 °C

To a solution of the compound from Example 7 (0.15 g, 0.5 mmol) and 1-iodo-3-(5-methyl-[1,3,4]oxadiazol-2-yl)benzene (0.14 g, 0.5 mmol) in triethylamine (5 mL) under an argon atmosphere was added trace tetrakis(triphenylphosphine)palladium(0) and trace copper(I) iodide. The mixture was heated at 80° C. for 0.2 h, was cooled to room temperature and was concentrated in vacuo. Purification by flash chromatography (silica gel, 50% EtOAc/hexane) provided the titled compound as a yellow oil (0.19 g, 80%). Anal. (C27H28N2O5· 0·375 H2O) calcd: C, 69.40; H, 6.20; N, 6.00. found: C, 69.23; H, 6.13;N,5.69.

1. temperaturewas cooled to room temperature
2. concentrationwas concentrated in vacuo
3. customPurification by flash chromatography (silica gel, 50% EtOAc/hexane)