Isonicotinamide → N-(2-t-Butyl-5-[(4-pyridyl)carbonylaminocarbonyl]phenyl)-3-(2,4-dimethoxyphenyl)octanamide

HRID 1637460Notes

Reaction equation

HRID 1637460 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11](O)=[O:12])=[CH:7][C:6]=1[NH:14][C:15](=[O:33])[CH2:16][CH:17]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=1[O:31][CH3:32])[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])([CH3:4])([CH3:3])[CH3:2].[C:34]([NH2:42])(=[O:41])[C:35]1[CH:40]=[CH:39][N:38]=[CH:37][CH:36]=1>C(OCC)(=O)C>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([NH:42][C:34]([C:35]2[CH:40]=[CH:39][N:38]=[CH:37][CH:36]=2)=[O:41])=[O:12])=[CH:7][C:6]=1[NH:14][C:15](=[O:33])[CH2:16][CH:17]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=1[O:31][CH3:32])[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 2

HCID 15074IsonicotinamideHCID 19348635HCID 19348635, compound

Product 1

HCID 19348755N-(2-t-Butyl-5-[(4-pyridyl)carbonylaminocarbonyl]phenyl)-3-(2,4-dimethoxyphenyl)octanamide

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Following a similar procedure to that described in Example 139, but using N-(2-t-butyl-5-carboxyphenyl)-3-(2,4-dimethoxyphenyl)octanamide (prepared as described in Preparation 7) and isonicotinamide, the title compound was obtained as crystals, melting at 184-185° C. (from ethyl acetate).

Sources & evidence

ORD record
ord-40bea00369454ec09e3835b6e4a9c597
Source dataset
uspto-grants-2000_03
Patent number
US06040339

Reaction notes

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