Diethyl Ether → HCID 86755255, compound

HRID 1637585Notes

Reaction equation

HRID 1637585 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:13][N:12]=[C:11]([NH:14][C:15](OC3C=CC=CC=3)=O)[CH:10]=2)=[CH:5][CH:4]=1.[C:24]1([N:30]2[CH2:35][CH2:34]NC[CH2:31]2)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.C([N:38]([CH2:41]C)CC)C.C([O:45]CC)C>C(Cl)(Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[NH:13][N:12]=[C:11]([N:14]3[CH2:15][CH2:31][N:30]([C:24]4[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=4)[CH2:35][CH2:34]3)[C:10]=2[N:38]=[C:41]=[O:45])=[CH:7][CH:8]=1

Participants

6

Reactant 4

HCID 3283Diethyl EtherHCID 70961-PhenylpiperazineHCID 8471TriethylamineHCID 18799524HCID 18799524, compound

Product 1

HCID 86755255HCID 86755255, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A mixture of 5-(4-methoxyphenyl)-3-phenoxycarbonylaminopyrazole (93 mg), 1-phenylpiperazine (54 mg) and triethylamine (91 mg) was heated under reflux for 2 hours in chloroform (3 ml). After the reaction solution was allowed to cool, ethyl ether (3 ml) was added thereto, and the thus precipitated crystals were collected by filtration and dried to obtain the title compound (103 mg) as colorless crystals (melting point: 235-245° C.).

Workup

  1. temperaturewas heated
  2. temperatureto cool
  3. filtrationthe thus precipitated crystals were collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-740efcc715214c0c83e86f6e7d7a15b7
Source dataset
uspto-grants-2000_03
Patent number
US06043246

Reaction notes

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