Chlorosuccinimide → HCID 18799400, compound

HRID 1637628Notes

Reaction equation

Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][OH:9])[CH:3]=1.[CH3:10][NH:11][CH2:12][CH2:13][CH2:14][OH:15].[Cl:16]N1C(=O)CCC1=O>>[Cl:16][C:3]1[C:4]([CH2:8][OH:9])=[N:5][CH:6]=[CH:7][C:2]=1[N:11]([CH3:10])[CH2:12][CH2:13][CH2:14][OH:15]

Participants

Reactant 3

HCID 31398Chlorosuccinimide

HCID 2763167(4-Chloropyridin-2-yl)methanol

HCID 101489863-(Methylamino)-1-propanol

Product 1

HCID 18799400HCID 18799400, compound

Procedure

As described in example D3., the title compound is prepared in two steps starting from (4-chloro-pyridin-2-yl)-methanol (15.3 g, 106 mmol) and 3-methylamino-propanol (10.0 g, 112 mmol) and subsequent chlorination of the crude product with N-chlorosuccinimide (19 g, 143 mmol). Yield: 6.4 g (26%), colourless oil.

Sources & evidence

ORD record: ord-89abf83d111e48a585d1bdc82a3c9abd
Source dataset: uspto-grants-2000_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06043242

Reaction notes

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