6-[3-(2-Chloromethyl-3-methylpyridin-4-ylsulfanyl)propylsulfanyl]-3-nitroimidazo[1,2-b]pyridazine → HCID 178503102, compound

HRID 1637634Notes

Reaction equation

HRID 1637634 reaction equation
[Cl:1][CH2:2][C:3]1[C:8]([CH3:9])=[C:7]([S:10][CH2:11][CH2:12][CH2:13][S:14][C:15]2[CH:16]=[CH:17][C:18]3[N:19]([C:21]([N+:24]([O-:26])=[O:25])=[CH:22][N:23]=3)[N:20]=2)[CH:6]=[CH:5][N:4]=1.[CH3:27][S:28][C:29]1[CH:30]=[CH:31][C:32]2[N:36]=[C:35]([SH:37])[NH:34][C:33]=2[CH:38]=1>C(O)(C)C>[ClH:1].[CH3:9][C:8]1[C:3]([CH2:2][S:37][C:35]2[NH:36][C:32]3[CH:31]=[CH:30][C:29]([S:28][CH3:27])=[CH:38][C:33]=3[N:34]=2)=[N:4][CH:5]=[CH:6][C:7]=1[S:10][CH2:11][CH2:12][CH2:13][S:14][C:15]1[CH:16]=[CH:17][C:18]2[N:19]([C:21]([N+:24]([O-:26])=[O:25])=[CH:22][N:23]=2)[N:20]=1

Participants

4

Reactant 2

HCID 187993836-[3-(2-Chloromethyl-3-methylpyridin-4-ylsulfanyl)propylsulfanyl]-3-nitroimidazo[1,2-b]pyridazineHCID 178503100HCID 178503100, compound

Product 1

HCID 178503102HCID 178503102, compoundYield 145.5%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

0.79 g (1.93 mmol) of 6-[3-(2-chloromethyl-3-methylpyridin-4-ylsulfanyl)propylsulfanyl]-3-nitro-imidazo[1,2-b]pyridazine and 0.41 g (1.1 mmol) of 6-methylsulfanyl-1H-benzoimidazole-2-thiol in 35 ml of isopropanol are reacted as described in Example 2. 0.97 g (97%) of the title compound of m.p. 193-195° C. is isolated.

Sources & evidence

ORD record
ord-f5b4d617ec5e4fc48528bdfb22ddcf50
Source dataset
uspto-grants-2000_03
Patent number
US06043242

Reaction notes

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