反应详情

570 mg (2.9 mmol) of 3-nitroimidazo[1,2-b]pyridazine-6-thiol, 500 mg (2.3 mmol) of [4-(3-chloropropoxy)-3-methylpyridin-2-yl]methanol and 0.4 ml (2.9 mmol) of triethylamine in 10 ml of dimethylformamide are heated to 100° C for 1 h under a nitrogen atmosphere. After cooling to room temperature, water (100 ml) is added and the mixture is extracted with 3×50 ml of ethyl acetate. The residual oil is crystallized from methanol. 600 mg (69%) of the title compound are isolated as a pale beige solid. M.p. 135-136° C.

1. extractionthe mixture is extracted with 3×50 ml of ethyl acetate
2. customThe residual oil is crystallized from methanol