Sodium hydride → HCID 70272534, compound

HRID 1637647Notes

Reaction equation

HRID 1637647 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[S:10][CH2:11][C:12]1[C:17]([Cl:18])=[C:16]([N:19]([CH3:24])[CH2:20][CH2:21][CH2:22][OH:23])[CH:15]=[CH:14][N:13]=1.Cl[C:26]1[CH:27]=[CH:28][C:29]2[N:30]([C:32]([N+:35]([O-:37])=[O:36])=[CH:33][N:34]=2)[N:31]=1.[H-].[Na+]>>[ClH:18].[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[S:10][CH2:11][C:12]1[C:17]([Cl:18])=[C:16]([N:19]([CH3:24])[CH2:20][CH2:21][CH2:22][O:23][C:26]2[CH:27]=[CH:28][C:29]3[N:30]([C:32]([N+:35]([O-:37])=[O:36])=[CH:33][N:34]=3)[N:31]=2)[CH:15]=[CH:14][N:13]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 105359816-Chloro-3-nitro-imidazo(1,2-b)pyridazineHCID 18799398HCID 18799398, compound

Product 1

HCID 70272534HCID 70272534, compound

Procedure

Starting from 3-{[2-(1H-benzimidazol-2-ylsulfanylmethyl)-3-chloropyridin-4-yl]-methylamino}-propan-1-ol (3.0 g, 8.2 mmol) (see example D2.), 6-chloro-3-nitro-imidazo[1,2-b]pyridazine (1.72 g, 8.7 mmol) and sodium hydride (0.62 g 80% strength suspension) the title compound is prepared and purified according to the procedure given for example 27. Yield: 1.95 g, (42%). M.p. 202-03° C.

Sources & evidence

ORD record
ord-905f6802cec0431682229edd12ac4407
Source dataset
uspto-grants-2000_03
Patent number
US06043242

Reaction notes

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