HCID 492870, compound → HCID 470504, compound

HRID 1637781Notes

Reaction equation

HRID 1637781 reaction equation
Cl[C:2]1[N:7]=[C:6]([S:8][CH2:9][C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:11]=2)[N:5]=[C:4]([C:20]#[N:21])[CH:3]=1.C1COCC1.[NH4+:27].[OH-]>C(OCC)(=O)C>[NH2:27][C:2]1[N:7]=[C:6]([S:8][CH2:9][C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:11]=2)[N:5]=[C:4]([C:20]#[N:21])[CH:3]=1

Participants

4

Reactant 2

HCID 492870HCID 492870, compoundHCID 86755259HCID 86755259, compound

Product 1

HCID 470504HCID 470504, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

6-chloro-2-(2-naphthylmethyl)thio-4-pyrimidine carbonitrile (Cpd 276; 60 mg, 3.07 mmol) was stirred in THF/NH4OH (1:1, 15 ml) at 22° C. for 6 hrs. The reaction was diluted with ethyl acetate, washed with brine, dried with MgSO4, then concentrated in vacuo: 871 mg (2.97 mmol, 97%), mp 154-155° C.

Workup

  1. washwashed with brine
  2. dry with materialdried with MgSO4
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-07ed5b93d9704a5589eeab7611f40f9a
Source dataset
uspto-grants-2000_03
Patent number
US06043248

Reaction notes

Loading…