Sodium Hydroxide → HCID 178481637, compound

HRID 1637923Notes

Reaction equation

HRID 1637923 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[C:13](OCC)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]1=[O:23])(=O)C.[NH2:24][C:25]1[CH:35]=[CH:34][C:28]2[N:29]([CH3:33])[C:30](=[O:32])[NH:31][C:27]=2[CH:26]=1.[OH-].[Na+]>CN(C=O)C.CO>[CH3:33][N:29]1[C:28]2[CH:34]=[CH:35][C:25]([NH:24]/[C:13](=[C:6]3\[C:5](=[O:23])[NH:4][C:12]4[C:7]\3=[CH:8][CH:9]=[CH:10][CH:11]=4)/[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[CH:26][C:27]=2[NH:31][C:30]1=[O:32]

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 155084375-Amino-1,3-dihydro-1-methyl-2H-benzimidazol-2-oneHCID 542378881-Acetyl-3-(1-ethoxy-1-phenylmethylidene}-2-indolinone

Product 1

HCID 178481637HCID 178481637, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6228DimethylformamideSolvent

Procedure

Prepared from 1-acetyl-3-{1-ethoxy-1-phenylmethylidene}-2-indolinone and 3 equivalents of crude 5-amino-1-methyl-2-oxo-2,3-dihydro-1H-benzimidazole in DMF followed by treatment with 1N sodium hydroxide solution in MeOH.

Sources & evidence

ORD record
ord-192519ceeafe40658ff16084c6c9f95a
Source dataset
uspto-grants-2000_03
Patent number
US06043254

Reaction notes

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